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KMID : 0604520170430020115
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Journal of the Society of Cosmetic Scientists of Korea
2017 Volume.43 No. 2 p.115 ~ p.124
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Studies on Skin Whitening Effects of Resorcinol Dipentyl Ether
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Cha Young-Kweon
Cho Hyun-Dae
Cho Wan-Goo
Byeon Sang-Yo
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Abstract
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The objective of this study was to investigate skin whitening effect of Resorcinol dipentyl ether [1,3-di(pentyloxyl)benzene] by in vitro experiments. Resorcinol dipentyl ether was prepared by alkylation of resorcinol with 1-bromopentane. The reaction products were confirmed by NMR, MS and other analytical equipments. In order to evaluate the skin safety of resorcinol dipentyl ether, the cytotoxicity of the cells constituting the skin (keratinocyte, melanocyte, fibroblast) was analyzed and similar cell viability was observed in all cell lines as compared with the control group. Inhibition of extracellular melanin synthesis effect of resorcinol dipentyl ether was approximately 65.75% at 20 μg/mL and inhibition of intracellular melanin synthesis effect of resorcinol dipentyl ether was approximately 53.89% at 20 μg/mL. The real-time PCR and western blot analysis of mRNA expression and protein expression of tyrosinase, TRP-1, and TRP-2 related to melanogenesis revealed that melanin inhibitory effect of resorcinol dipentyl ether was inhibited from the transcription stage respectively. Finally, this study suggested applicability of Resorcinol dipentyl ether [1,3-di(pentyloxyl)benzene] as a whitening functional cosmetic new material.
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KEYWORD
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Resorcinol dipentyl ether , melanin , MTT assay , tyrosinase , mRNA
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